Year: 2017 | Month: August | Volume 7 | Issue 4
Effects of Oral Feeding of Coumestrol on Efferent Ductules in Dogs
Abstract:
The present study was conducted on ten healthy adult stray male dogs weighing 12 - 19 kg, and randomly divided into two groups. Animals in treatment group (n = 5) were given coumestrol dissolved in di-methyl sulfoxide (DMSO) orally as single dose @ 1.5 mg/kg body weight. Dogs in control group (n = 5) were given DMSO only. Castration of the treated dogs was done on 12 hours, 24 hours, 7 days, and 15th day post feeding of coumestrol; same castration schedule was followed for control group also. Histopathology revealed normal efferent ductules epithelium after coumestrol feeding. There were no any changes seen that would be responsible to lead infertility in male dogs. Therefore, from this study, it was concluded that oral feeding of coumestrol @ 1.5 mg/kg b.w. has no adverse effects on efferent ductules and therefore it cannot be used for population control of dogs.
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